What is published
The Biochemistry metabolism map draws Reactome's human metabolism as a single network in which pathways share their molecules, with exact ChEBI structures, enzymes and recent literature attached. It sits in the Learning sector because its job is teaching; the graph construction and layout are the research behind it.
Two instruments model the chemistry directly. Neuron integrates the Hodgkin–Huxley equations for a patch of squid axon membrane. Enzyme kinetics compares competitive, uncompetitive and mixed inhibition and runs the Sel'kov model of glycolytic oscillation.
The site also carries a release-locked evidence corpus for human α-carbonic anhydrases: 15 protein dossiers with structures, assays and reaction assignments, each traced to its source record.
Questions being worked on
- How to lay out thousands of reactions so that shared intermediates, compartments and pathway territories stay readable at every zoom level.
- How to attach enzyme, structure and literature evidence to a reaction without implying flux or tissue abundance the sources do not support.
- Whether the map's reaction graph can serve as the network definition for kinetic simulation of central carbon metabolism, a concept under study.
Sources
Reactome (pathways, reactions, catalysts), ChEBI (structures), Rhea (reaction identities), UniProt (reviewed human enzymes) and Europe PMC (recent literature), each with its licence shown beside the data.
Revised 25 October 2026. Questions and corrections: [email protected]